Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


___


Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Te'o Denies Involvement in Girlfriend Hoax













Notre Dame star linebacker Manti Te'o told ESPN that he "never, not ever" was involved in creating the hoax that had him touting what turned out to be a fictional girlfriend, "Lennay Kekua."


"When they hear the facts, they'll know," Te'o told ESPN's Jeremy Schaap in his first interview since the story broke. "They'll know that there is no way that I could be a part of this."


"I wasn't faking it," he said during a 2 1/2-hour interview, according to ESPN.com.


Te'o said he only learned for sure this week that he had been duped. On Wednesday, he received a Twitter message, allegedly from a man named Ronaiah Tuiasosopo, apologizing for the hoax, Te'o told Schaap.


The sports website Deadspin, which first revealed the hoax this week, has reported that Tuiasosopo, a 22-year-old of Samoan descent who lives in Antelope Valley, Calif., asked a woman he knew for her photo and that photo became the face of Kekua's Twitter account.


Te'o told Schaap that Tuiasosopo was represented to him as Kekua's cousin.


"I hope he learns," Te'o said of Tuiasosopo, according to coverage of the interview on ESPN.com. "I hope he understands what he's done. I don't wish an ill thing to somebody. I just hope he learns. I think embarrassment is big enough."


Click Here for a Who's Who in the Manti Te'o Case






AP Photo/ESPN Images, Ryan Jones











Manti Te'o Hoax: Was He Duped or Did He Know? Watch Video









Manti Te'o Hoax: Notre Dame Star Allegedly Scammed Watch Video









Tale of Notre Dame Football Star's Girlfriend and Her Death an Alleged Hoax Watch Video





Te'o admitted to a few mistakes in his own conduct, including telling his father he met Kekua in Hawaii even though his attempt to meet her actually failed. Later retellings of that tale led to inconsistencies in media reports, Te'o said, adding that he never actually met Kekua in person.


Te'o added that he feared people would think it was crazy for him to be involved with someone that he never met, so, "I kind of tailored my stories to have people think that, yeah, he met her before she passed away."


The relationship got started on Facebook during his freshman year, Te'o said.


"My relationship with Lennay wasn't a four-year relationship," Te'o said, according to ESPN.com. "There were blocks and times and periods in which we would talk and then it would end."


He showed Schaap Facebook correspondence indicating that other people knew of Kekua -- though Te'o now believes they, too, were tricked.


The relationship became more intense, Te'o said, after he received a call that Kekua was in a coma following a car accident involving a drunk driver on April 28.


Soon, Te'o and Kekua became inseparable over the phone, he said, continuing their phone conversations through her recovery from the accident, and then during her alleged battle against leukemia.


Even so, Te'o never tried to visit Kekua at her hospital in California.


"It never really crossed my mind," he said, according to ESPN.com. "I don't know. I was in school."


But the communication between the two was intense. They even had ritual where they discussed scripture every day, Te'o said. His parents also participated via text message, and Te'o showed Schaap some of the texts.


On Sept. 12, a phone caller claiming to be Kekua's relative told Te'o that Kekua had died of leukemia, Te'o said. However, on Dec. 6, Te'o said he got a call allegedly from Kekua saying she was alive. He said he was utterly confused and did not know what to believe.


ESPN's 2 1/2-hour interview was conducted in Bradenton, Fla., with Te'o's lawyer present but without video cameras. Schaap said Te'o was composed, comfortable and in command, and that he said he didn't want to go on camera to keep the setting intimate and avoid a big production.


According to ABC News interviews and published reports, Te'o received phone calls, text messages and letters before every football game from his "girlfriend." He was in contact with her family, including a twin brother, a second brother, sister and parents. He called often to check in with them, just as he did with his own family. And "Kekua" kept in contact with Te'o's friends and family, and teammates spoke to her on the phone.






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Algerian army stages "final assault" on gas plant


ALGIERS/IN AMENAS, Algeria (Reuters) - The Algerian army on Saturday carried out a final assault on al Qaeda-linked gunmen holed up in a desert gas plant, killing 11 of the Islamists after they took the lives of seven more foreign hostages, a local source and the state news agency said.


"It is over now, the assault is over, and the military are inside the plant clearing it of mines," a local source familiar with the operation told Reuters.


The state oil and gas company, Sonatrach, said the militants who attacked the plant on Wednesday and took a large number of hostages had booby-trapped the complex with explosives.


The exact death toll among the gunmen and the foreign and Algerian workers at the plant near the town of In Amenas close to the Libyan border remained unclear.


Earlier on Saturday, Algerian special forces found 15 burned bodies at the plant. Efforts were under way to identify the bodies, the source told Reuters, and it was not clear how they had died.


Sixteen foreign hostages were freed on Saturday, a source close to the crisis said. They included two Americans, two Germans and one Portuguese. Britain said fewer than 10 of its nationals at the plant were unaccounted for.


The attack on the plant swiftly turned into one of the biggest international hostage crises in decades, pushing Saharan militancy to the top of the global agenda.


INTERNATIONAL CRISIS


It marked a serious escalation of unrest in northwestern Africa, where French forces have been in Mali since last week fighting an Islamist takeover of Timbuktu and other towns.


The captors said their attack was a response to the French offensive. However, some U.S. and European officials say the elaborate raid probably required too much planning to have been organized from scratch in the week since France launched its strikes.


Scores of Westerners and hundreds of Algerian workers were inside the heavily fortified gas compound when it was seized before dawn on Wednesday by Islamist fighters who said they wanted a halt to the French intervention in neighboring Mali.


Hundreds escaped on Thursday when the army launched a rescue operation, but many hostages were killed.


Before the final assault, different sources had put the number of hostages killed at between 12 and 30, with many foreigners still unaccounted for, among them Norwegians, Japanese, Britons and Americans.


The figure of 30 came from an Algerian security source, who said eight Algerians and at least seven foreigners were among the victims, including two Japanese, two Britons and a French national. One British citizen was killed when the gunmen seized the hostages on Wednesday.


The U.S. State Department said on Friday one American, Frederick Buttaccio, had died but gave no further details.


Leaders of Britain, Japan and other countries have expressed frustration that the assault was ordered without consultation and officials have grumbled at the lack of information.


France's defense minister, Jean-Yves Le Drian, declined to criticize the Algerian response to the crisis, however.


"The Algerian authorities are on their own soil and responding in the fashion they can. The overriding mission is to tackle the terrorists," he told France 3 television.


The base was home to foreign workers from Britain's BP, Norway's Statoil, Japanese engineering firm JGC Corp and others.


VETERAN JIHADIST


The apparent ease with which the fighters swooped in from the dunes to take control of an important energy facility, which produces some 10 percent of the natural gas on which Algeria depends for its export income, has raised questions over the value of outwardly tough Algerian security measures.


Algerian officials said the attackers may have had inside help from among the hundreds of Algerians employed at the site.


France says the incident proves its decision to fight Islamists in neighboring Mali was necessary.


The field commander of the Islamist group that attacked the plant is a veteran fighter from Niger called Abdul Rahman al-Nigeri, Mauritanian news agencies reported.


Security in the half-dozen countries around the Sahara desert has long been a preoccupation of the West. Smugglers and militants have earned millions in ransom from kidnappings.


The most powerful Islamist groups operating in the Sahara were severely weakened by Algeria's secularist military in a civil war in the 1990s. But in the past two years the regional wing of al Qaeda gained fighters and arms as a result of the civil war in Libya, when arsenals were looted from Muammar Gaddafi's army.


Al Qaeda-linked fighters, many with roots in Algeria and Libya, took control of northern Mali last year.


(Additional reporting by Balazs Koranyi in Oslo, Estelle Shirbon in London, Brian Love in Paris; Writing by Giles Elgood; Editing by Sonya Hepinstall and Mark Trevelyan)



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SNCF to launch grant framework for social entrepreneurs






SINGAPORE: To facilitate the growth of co-operatives, the Singapore National Co-operative Federation (SNCF) will launch a comprehensive grant framework that gives budding social entrepreneurs the support they need to set up new co-operatives to deal with social needs that have yet to be met.

Existing co-operatives will also be able to use the grant to improve productivity, expand their services, and for staff development.

This was announced by SNCF Chairman Chan Tee Seng at an awards ceremony on Saturday to recognise 22 co-operatives, co-operators and supporters for their contributions toward improving the welfare of Singaporeans.

The awards commend those who have helped grow the Singapore Co-operative Movement, which includes areas such as thrift and loan, aged care, childcare, employment, and insurance.

Minister in the Prime Minister's Office Lim Swee Say and former Singapore President SR Nathan were also among those recognised as co-op champions for the support they have rendered to the co-operative movement.

Mr Lim praised the role of co-operatives here, calling them both competent and competitive.

"Here at home, our co-operatives and social enterprises are doing your best as active citizens. It's in your DNA to do good -- passion to help others to live a better life. It's in your DNA to do well -- competent and competitive, to be financially viable. How can we help others, if we're not able to help ourselves? Most of all, it's in your DNA to do more, and to do more together," he said.

Mr Lim urged individual co-operatives here to work as a network, and in partnership with other like-minded enterprises so as to meet the ever-increasing needs of the community.

As a way to encourage co-operatives to come together, the SNCF also plans to facilitate and co-pay a shared services platform that will allow these co-operatives to collaborate and develop shared services in the areas of IT, marketing, book-keeping and accounting.

-CNA/ac



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Lalu bats for Rahul Gandhi as PM candidate

KOLKATA: RJD leader Lalu Prasad Yadav today batted for Congress general secretary Rahul Gandhi to be the Prime Ministerial candidate for the 2014 general elections, and said Gujarat chief minister Narendra Modi's "dream of becoming PM will never come true".

"Modi's prime ministerial dream is not going to come true... His dream of coming to Hastinapur will never materialise," he said, retorting, "What is wrong with Rahul Gandhi, tell me?"

Prasad was talking to reporters on the sidelines of a FICCI Ladies Organisation programme here.

A dozen people were being projected as Prime Minister, but it did not mean that they would become the one, he said.

He also ruled out formation of a third front during the Lok Sabha polls in 2014 and said, "I have been in politics for a long time now and I can tell you a third party has never come to power, nor will it ever come to power...

"There will be only two compartments, communal compartment and secular compartment, and the secular compartment will form the government," he said.

Prasad praised Congress President Sonia Gandhi's leadership and her move for making Manmohan Singh the Prime Minister in 2004.

"She is not a foreigner. She is the daughter-in-law of India. She has proved her large heartedness by refusing the post of prime minister in 2004," he said.

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Food service vulnerable to food allergy lawsuits


WASHINGTON (AP) — People with severe food allergies have a new tool in their attempt to find menus that fit their diet: federal disabilities law. And that could leave schools, restaurants and anyplace else that serves food more vulnerable to legal challenges over food sensitivities.


A settlement stemming from a lack of gluten-free foods available to students at a Massachusetts university could serve as a precedent for people with other allergies or conditions, including peanut sensitivities or diabetes. Institutions and businesses subject to the Americans With Disabilities Act could be open to lawsuits if they fail to honor requests for accommodations by people with food allergies.


Colleges and universities are especially vulnerable because they know their students and often require them to eat on campus, Eve Hill of the Justice Department's civil rights division says. But a restaurant also could be liable if it blatantly ignored a customer's request for certain foods and caused that person to become ill, though that case might be harder to argue if the customer had just walked in off the street, Hill says.


The settlement with Lesley University, reached last month but drawing little attention, will require the Cambridge, Mass., institution to serve gluten-free foods and make other accommodations for students who have celiac disease. At least one student complained to the federal government after the school would not exempt the student from a meal plan even though the student couldn't eat the food.


"All colleges should heed this settlement and take steps to make accommodations," says Alice Bast, president and founder of the National Foundation for Celiac Awareness. "To our community this is definitely a precedent."


People who suffer from celiac disease don't absorb nutrients well and can get sick from the gluten found in wheat, rye and barley. The illness, which affects around 2 million Americans, causes abdominal pain, bloating and diarrhea, and people who have it can suffer weight loss, fatigue, rashes and other problems. Celiac is a diagnosed illness that is more severe than gluten sensitivity, which some people self-diagnose.


Ten years ago, most people had never heard of celiac disease. But awareness has exploded in recent years, for reasons that aren't entirely clear. Some researchers say it was under-diagnosed, others say it's because people eat more processed wheat products like pastas and baked goods than in past decades, and those items use types of wheat that have a higher gluten content.


Gluten-free diets have expanded beyond those with celiac disease. Millions of people are buying gluten-free foods because they say they make them feel better, even if they don't have a wheat allergy. Americans were expected to spend $7 billion on gluten-free foods last year.


With so many people suddenly concerned with gluten content, colleges and universities have had to make accommodations. Some will allow students to be exempted from meal plans, while others will work with students individually. They may need to do even more now as the federal government is watching.


"These kids don't want to be isolated," Bast says. "Part of the college experience is being social. If you can't even eat in the school cafeteria then you are missing out on a big part of college life."


Under the Justice Department agreement, Lesley University says it will not only provide gluten-free options in its dining hall but also allow students to pre-order, provide a dedicated space for storage and preparation to avoid cross-contamination, train staff about food allergies and pay a $50,000 cash settlement to the affected students.


"We are not saying what the general meal plan has to serve or not," Hill says. "We are saying that when a college has a mandatory meal plan they have to be prepared to make reasonable modifications to that meal plan to accommodate students with disabilities."


The agreement says that food allergies may constitute a disability under the Americans With Disabilities Act, if they are severe enough. The definition was made possible under 2009 amendments to the disability law that allowed for episodic impairments that substantially limit activity.


"By preventing people from eating, they are really preventing them from accessing their educational program," Hill says of the school and its students.


Mary Pat Lohse, the chief of staff and senior adviser to Lesley University's president, says the school has been working with the Justice Department for more than three years to address students' complaints. She says the school has already implemented most parts of the settlement and will continue to update policies to serve students who need gluten-free foods.


"The settlement agreement provides a positive road map for other colleges and universities to follow," Lohse says.


Joan Rector McGlockton of the National Restaurant Association says that restaurants have taken notice of an increasing demand for gluten free options, "drawing attention to the importance of providing these options as well as the preparation methods involved in serving these options."


The group has a training program for restaurants so they will know what to do when food allergy issues arise.


Some say the Justice Department decision goes too far. Hans von Spakovsky, a fellow at the conservative Heritage Foundation who worked in the civil rights division of the Justice Department under President George W. Bush, says food allergies shouldn't apply under the disability act. He adds that the costs could be substantial when schools are already battling backlash from high tuition costs.


"I certainly encourage colleges and universities to work with students on this issue, but the fact that this is a federal case and the Justice Department is going to be deciding what kind of meals could be served in a dining hall is just absurd," he says.


Whether the government is involved or not, schools and other food service establishments are likely to hear from those who want more gluten-free foods. Dhanu Thiyagarajan, a sophomore at the University of Pittsburgh, says she decided to speak up when she arrived at school and lost weight because there were too few gluten-free options available. Like Lesley University, the University of Pittsburgh requires that on-campus students participate in a meal plan.


Thiyagarajan eventually moved off campus so she could cook her own food, but not before starting an organization of students who suffer from wheat allergies like hers. She says she is now working with food service at the school and they have made a lot of progress, though not enough for her to move back on campus.


L. Scott Lissner, the disability coordinator at Ohio State University, says he has seen similar situations at his school, though people with food allergies have not traditionally thought of themselves as disabled. He says schools will eventually have to do more than just exempt students from a meal plan.


"This is an early decision on a growing wave of needs that universities are going to have to address," he says of the Lesley University agreement.


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Follow Mary Clare Jalonick on Twitter at http://twitter.com/mcjalonick


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Manti Te'o's Fake Girlfriend May Have Duped Others













Notre Dame star linebacker Manti Te'o's fake girlfriend "Lennay Kekua" may have hoaxed other unsuspecting suitors.


"Catfish" movie director and actor Ariel Schulman told "Good Morning America" today that he believes there may have been "a few other people duped by the fake Lennay character."


Schulman and his brother Nev Schulman have been looking into the elaborate scam and claim to be corresponding with various players involved. They have come to believe that there were "a lot of other people that she was corresponding with before and maybe even during her relationship [with Te'o]."


Nev Schulman was the subject of the 2010 movie "Catfish," which spawned the TV series, because he himself was sucked in by an Internet pretender -- or a "catfish" -- who built an elaborate fake life.


As questions mount about Te'o's possible role in the complex scam, the number one question is whether Te'o was unknowingly ensnared, as he says, or whether he was complicit in the scam.


"I stand by the guy. My heart goes out to him," Ariel Schulman said. His brother has reached out to Te'o, but has not heard back.


"He had his heart broken," Schulman said. "He was grieving for someone, whether she existed or not. Those were real feelings."






Streeter Lecka/Getty Images











Manti Te'o Hoax: Was He Duped or Did He Know? Watch Video









Manti Te'o Hoax: Notre Dame Star Allegedly Scammed Watch Video









Tale of Notre Dame Football Star's Girlfriend and Her Death an Alleged Hoax Watch Video





Click here for a who's who in the Manti Te'o case


Te'o has kept a low-profile since the news of the scandal broke. He released a statement calling the situation "incredibly embarrassing" and maintaining that he was a victim of the hoax.


He was captured briefly by news cameras on Thursday at a Florida training facility, but has not spoken publicly.


As for the woman whose photo was used as the face of Lennay Kekua, "Inside Edition" has identified her as Diane O'Meara who is very much alive. The show caught up with her on Thursday, but she declined to comment.


ABC News' legal analyst Dan Abrams said that O'Meara may be the one person in the scandal with the power to sue since her likeness was taken and used without her permission.


As for Te'o, even if he knew about the deception, it appears that he did not do anything illegal.


"He's allowed to lie to the public. He's allowed to lie to the media. He's not allowed to lie to the authorities," Abrams said on "Good Morning America."


Questions also remain about the timeline of events and when Te'o discovered that the "love of his life," as he called her, was nothing more than a fake Internet persona.


According to Notre Dame's timeline of events, Te'o learned his girlfriend didn't exist on Dec. 6.


But in a Dec. 8 interview with South Bend, Ind., TV station WSBT, Te'o said, "I really got hit with cancer. I lost both my grandparents an my girlfriend to cancer." And on Dec. 11, he talked about his girlfriend in a newspaper interview.


Te'o alerted Notre Dame on Dec. 26 about the scam, the university said.


Click here for more scandalous public confessions.


Skeptics have also cited comments by Te'o's father Brian Te'o who told a newspaper how Kekua used to visit his son in Hawaii.


Notre Dame athletic director Jack Swarbrick said the university launched their own investigation.


"Our investigators, through their work, were able to discover online chatter between the perpetrators," Swarbrick said at a Wednesday news conference. "That was sort of the ultimate proof."






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Sixty foreigners still caught in Sahara hostage crisis


ALGIERS (Reuters) - About 60 foreigners were still being held hostage or missing inside a gas plant on Friday after Algerian forces stormed the desert complex to free hundreds of captives taken by Islamist militants, who threatened to attack other energy installations.


The attack, which plunged capitals around the world into crisis mode, is a serious escalation of unrest in northwestern Africa, where French forces have been in Mali since last week fighting an Islamist takeover of Timbuktu and other towns.


"We are still dealing with a fluid and dangerous situation where a part of the terrorist threat has been eliminated in one part of the site, but there still remains a threat in another part," British Prime Minister David Cameron told his parliament.


A local Algerian source said 60 foreigners were still in the facility and some were being held hostage, but it was unclear how many and how many might be in hiding elsewhere in the sprawling compound. It was also not known whether some might have been killed and the bodies not found.


Those still unaccounted for included 10 from Japan, eight Norwegians and a number of Britons put by Cameron at "less than 30". Washington has said a number of Americans were among the hostages, without giving details, and the local source said a U.S. aircraft landed nearby on Friday.


As Western leaders clamored for news of their nationals, several expressed anger they had not been consulted by the Algerian government about its decision to storm the facility.


Algeria's state news agency said earlier more than half of 132 foreign hostages were freed and that the army had rescued 650 hostages, 573 of whom were Algerians.


"(The army) is still trying to achieve a ‘peaceful outcome' before neutralizing the terrorist group that is holed up in the (facility) and freeing a group of hostages that is still being held," it said, quoting a security source.


Thirty hostages, including several Westerners, were killed during Thursday's assault, the source said, along with at least 18 of their captors, who said they had taken the site as retaliation for French intervention against Islamists in neighboring Mali.


(Additional reporting by Ali Abdelatti in Cairo, Eamonn Mallie in Belfast, Gwladys Fouche in Oslo, Mohammed Abbas in London and Padraic Halpin and Conor Humprhies in Dublin; Writing by Philippa Fletcher; Editing by Alastair Macdonald)



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Football: 'Guardiola to City' talk did not faze Mancini






MANCHESTER, United Kingdom: Roberto Mancini on Friday said that he was never concerned about the prospect of Pep Guardiola taking his job at Manchester City, despite speculation before the Spaniard joined Bayern Munich.

Guardiola, the former Barcelona coach, was said to be lined up for a move to Eastlands should Mancini fail to deliver a trophy this year, despite leading the club to the English Premier League title last term.

The arrival at City of former Barca directors Ferran Soriano and Txiki Begiristain as chief executive and director of football only fuelled the rumours that the champions were building a backroom team for Guardiola.

But Guardiola is now set to take over at the German giants from next season, after signing a three-year contract earlier this week.

"I think that after one year out of work he decided to go to an important team," he told a news conference. "Bayern Munich is one of the world's top clubs because of its history. He decided this because it was the best solution for him.

"I did not have any problems about (the speculation of a move to City)," he added. "I understand the newspapers write that every day every manager wants to come here because it's a good place. But I think we work very well here.

"I have a five-year contract," he said, adding that he did not think it was likely that that he would be replaced in the meantime.

Mancini, whose side are currently seven points behind league leaders and local rivals Manchester United, said that although he wants to add to his squad, he may only be able to sign young players instead of big names in the transfer window.

"I think in January it is difficult to take good players because there is not one club who can sell good players," he explained.

"Maybe we can find some young players if we get a chance. In the last 12 days we probably can do something but I am not sure."

Mancini also welcomed a move to rescind a red card handed to City defender Vincent Kompany for a challenge on Jack Wilshere in last weekend's win over Arsenal, allowing him to escape a three-match ban.

"I am very pleased because I think it (the decision) is correct," said the manager. "I think the referee managed the game very well but in that situation he did not get to see well. After, I think he did very well.

"I don't think that tackle was a red card. Sometimes it's not."

Mancini meanwhile revealed that Sergio Aguero will return to action in City's home game against Fulham on Saturday, as the Argentina international has completed his recovery from a hamstring injury.

Aguero has not played since City beat Stoke on New Year's Day.

Mancini said he was relieved City appear to have overcome several recent injury problems, with the manager blaming the Premier League's hectic schedule for the club's fitness problems.

"We don't have time to recover, this is the reason," he added. "If every player play every two days for one year then they go and play international football there is no time to recover."

- AFP/de



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Large study confirms flu vaccine safe in pregnancy


NEW YORK (AP) — A large study offers reassuring news for pregnant women: It's safe to get a flu shot.


The research found no evidence that the vaccine increases the risk of losing a fetus, and may prevent some deaths. Getting the flu while pregnant makes fetal death more likely, the Norwegian research showed.


The flu vaccine has long been considered safe for pregnant women and their fetus. U.S. health officials began recommending flu shots for them more than five decades ago, following a higher death rate in pregnant women during a flu pandemic in the late 1950s.


But the study is perhaps the largest look at the safety and value of flu vaccination during pregnancy, experts say.


"This is the kind of information we need to provide our patients when discussing that flu vaccine is important for everyone, particularly for pregnant women," said Dr. Geeta Swamy, a researcher who studies vaccines and pregnant women at Duke University Medical Center.


The study was released by the New England Journal of Medicine on Wednesday as the United States and Europe suffer through an early and intense flu season. A U.S. obstetricians group this week reminded members that it's not too late for their pregnant patients to get vaccinated.


The new study was led by the Norwegian Institute of Public Health. It tracked pregnancies in Norway in 2009 and 2010 during an international epidemic of a new swine flu strain.


Before 2009, pregnant women in Norway were not routinely advised to get flu shots. But during the pandemic, vaccinations against the new strain were recommended for those in their second or third trimester.


The study focused on more than 113,000 pregnancies. Of those, 492 ended in the death of the fetus. The researchers calculated that the risk of fetal death was nearly twice as high for women who weren't vaccinated as it was in vaccinated mothers.


U.S. flu vaccination rates for pregnant women grew in the wake of the 2009 swine flu pandemic, from less than 15 percent to about 50 percent. But health officials say those rates need to be higher to protect newborns as well. Infants can't be vaccinated until 6 months, but studies have shown they pick up some protection if their mothers got the annual shot, experts say.


Because some drugs and vaccines can be harmful to a fetus, there is a long-standing concern about giving any medicine to a pregnant woman, experts acknowledged. But this study should ease any worries about the flu shot, said Dr. Denise Jamieson of the Centers for Disease Control and Prevention.


"The vaccine is safe," she said.


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Online:


Medical journal: http://www.nejm.org


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